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. 2020 Apr;9(2):646–653. doi: 10.21037/tau.2019.12.10

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2020 Translational Andrology and Urology. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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miR-30a-3p targets ATG12 by binding its 3'UTR. (A) Analysis of the potential signaling pathways of miR-30a-3p according to the KEGG database. (B) Venn figure indicated ATG12 was the only overlap of genes involved in FOXO signaling pathway and potential target genes of miR-30a-3p. (C) Bioinformatic analysis reveals the potential ATG12-binding sites in miR-30a-3p. (D) Luciferase reporter assays of ATG12 in 786-O cells. (E,F) Western blot of ATG12 protein levels in miR-30a-3p compared to miR-NC. (E), miR-30a-3p inhibitor compared to miR-NC inhibitor; and (F) miR-30a-3p mimic compared to miR-NC mimic. (G) Spearman’s correlation analysis of miR-30a-3p and ATG12 expression in RCC tissues from TCGA database. RCC, renal cell carcinoma.