Table 3. Functional roles of 13 hub genes with degree ≥10.

No.	Gene symbol	Full name	Function
1	SPAG5	Sperm associated antigen 5	Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase
2	EXO1	Exonuclease 1	Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch
3	MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	Component of the spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate
4	BIRC5	Baculoviral IAP repeat-containing 5	Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis
5	MKI67	Marker of proliferation Ki-67	Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly
6	CENPN	Centromere protein N	Component of the CENPA-NAC complex, a complex that plays a vital role in the assembly of kinetochore proteins, mitotic progression, and chromosome segregation
7	CDCA5	Cell division cycle associated 5	Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin
8	KIF22	Kinesin family member 22	Kinesin family member that participates in spindle formation and the movements of chromosomes during mitosis and meiosis
9	KIF20A	Kinesin family member 20A	Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis
10	CDC25C	Cell division cycle 25C	Functions as a dosage-dependent inducer in mitotic control
11	CKAP2	Cytoskeleton-associated protein 2	Possesses microtubule-stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity)
12	KIF14	Kinesin family member 14	Regulates cell growth through regulation of cell cycle progression and cytokinesis
13	KIF18A	Kinesin family member 18A	Microtubule-depolymerizing kinesin, which plays a role in chromosome congression