Table 2. Significant predictors of OS identified by multivariate analyses in 531 ccRCC patients.

Characteristic	Univariate				Multivariate
	P value	HR	95% CI		P value	HR	95% CI
Age >65	0.001	1.645	1.221–2.216		0.011	1.494	1.097–2.034
Female	0.737	0.949	0.697–1.291
ZIC2 >1.47	<0.001	3.160	2.345–4.259		0.006	1.625	1.146–2.302
T stage	<0.001	3.138	2.320–4.245		0.643	0.869	0.479–1.575
N stage	<0.001	3.843	2.081–7.097		0.079	1.763	0.936–3.323
M stage	<0.001	4.367	3.207–5.945		<0.001	2.055	1.396–3.025
Histologic grade	<0.001	2.653	1.895–3.716		0.033	1.505	1.033–2.192
TNM stage (III/IV)	<0.001	3.835	2.798–5.256		0.016	2.311	1.166–4.580

ZIC2, zinc finger of the cerebellum 2; OS, overall survival; ccRCC, clear cell renal cell carcinoma; HR, hazard ratio.