Fig. 4.

Mean DPX plasma concentration versus time following buccal administration of optimized instantly dissolving film compared to oral reference tablet in rats and computed in vivo pharmacokinetic parameters (Inset table). &Data represent the mean value ± standard deviation (SD), n = 12. ^ Data represent the median, n = 12 * Significant at P < 0.05, test of significance using Two-way ANOVA, Sidak's multiple comparisons test ^# Significant at p < 0.05, test of significance using unpaired t test (two-tailed) with Welch’s correction ^$ Significant at p < 0.05, test of significance using Mann-Whitney test.