Table 1.
Independent variables and responses used in 32 full factorial experimental design for the formulation and optimization of dapoxetine hydrochloride instantly dissolving buccal films.
| Independent variables | Levels |
||
|---|---|---|---|
| (−1) | (0) | (+1) | |
| X1: HPMC E5: MDX (w/w) | 1:3 | 1:1 | 3:1 |
| X2: PG % | 1.00 | 3.00 | 5.00 |
| Responses | Desirability constraints | ||
| Y1: TS (MPa) | Minimize | ||
| Y2: % E (%) | Maximize | ||
| Y3: EM (MPa) | Minimize | ||
| Y3: % D5min (%) | Maximize | ||
| Y3: In vivo MDT (sec) | Minimize | ||
HPMC E5; Hydroxypropyl methyl cellulose E5, PG; Propylene glycol.
TS; Tensile strength, % E; Percent elongation at break, EM; Elastic (Young’s) modulus, % D5min; Percent drug dissolved after 5 min, In vivo MDT; In vivo mouth dissolving time