Table 2.
Composition and responses of dapoxetine hydrochloride instantly dissolving buccal films prepared according 32 full factorial design.
| Run | Independent Variables |
Responses (Dependent Variable) |
|||||
|---|---|---|---|---|---|---|---|
| HPMC E5: MDX (w/w, X1)* | PG (%, X2) | TS$ (MPa, Y1) | % E$ (%, Y2) | EM$ (MPa, Y3) | D5 min# (%, Y4) | MDT# (sec, Y5) | |
| F1 | 1:3 | 1.00 | 0.217 ± 0.014 | 147.97 ± 2.56 | 0.146 ± 0.009 | 84.76 ± 3.98 | 9.67 ± 0.56 |
| F2 | 1:3 | 3.00 | 0.434 ± 0.038 | 235.68 ± 5.14 | 0.184 ± 0.019 | 75.97 ± 4.23 | 14.32 ± 1.78 |
| F3 | 1:3 | 5.00 | 0.567 ± 0.043 | 273.88 ± 2.14 | 0.207 ± 0.031 | 71.21 ± 2.11 | 12.89 ± 0.78 |
| F4 | 1:1 | 1.00 | 0.811 ± 0.077 | 115.34 ± 1.56 | 0.703 ± 0.065 | 66.91 ± 2.45 | 13.15 ± 1.77 |
| F5 | 1:1 | 3.00 | 1.330 ± 0.098 | 144.56 ± 1.98 | 0.920 ± 0.087 | 72.12 ± 1.33 | 14.98 ± 0.81 |
| F6 | 1:1 | 5.00 | 1.934 ± 0.145 | 216.31 ± 3.87 | 0.894 ± 0.091 | 46.54 ± 0.98 | 19.12 ± 1.44 |
| F7 | 3:1 | 1.00 | 1.16 ± 0.156 | 92.35 ± 1.19 | 2.338 ± 0.134 | 52.98 ± 0.99 | 22.67 ± 1.65 |
| F8 | 3:1 | 3.00 | 4.22 ± 0.257 | 57.05 ± 0.99 | 7.397 ± 0.219 | 38.41 ± 1.14 | 23.54 ± 1.98 |
| F9 | 3:1 | 5.00 | 6.45 ± 0.549 | 39.52 ± 1.88 | 16.321 ± 0.341 | 37.08 ± 2.13 | 25.12 ± 2.12 |
HPMC E5; Hydroxypropyl methyl cellulose E5, MDX; maltodextrin, PG; Propylene glycol.
TS; tensile strength, %E; percentage elongation, EM; Elastic (Young’s) modulus, % D5min; Percent drug dissolved after 5 min, MDT; In vivo mouth- dissolving time, Values are expressed as mean ± SD; # n = 3, $n = 6.