Table 3.
Characterization and equilibrium moisture uptake of dapoxetine hydrochloride instantly dissolving buccal films prepared according 32 full factorial design.
| Run | Weight& (mg) | Thickness$ (mm) | Drug content (%)& | Moisture uptake* (%)# |
|---|---|---|---|---|
| F1 | 76.81 ± 6.11 | 0.24 ± 0.02 | 96.21 ± 1.58 | 8.68 ± 0.56 |
| F2 | 78.12 ± 5.45 | 0.29 ± 0.04 | 98.33 ± 4.12 | 12.46 ± 0.98 |
| F3 | 65.15 ± 4.33 | 0.26 ± 0.04 | 106.27 ± 2.74 | 14.90 ± 1.21 |
| F4 | 68.34 ± 6.21 | 0.30 ± 0.11 | 104.73 ± 2.91 | 8.82 ± 0.87 |
| F5 | 82.43 ± 7.13 | 0.35 ± 0.07 | 97.12 ± 1.79 | 10.17 ± 0.91 |
| F6 | 75.32 ± 6.98 | 0.32 ± 0.06 | 102.34 ± 1.52 | 11.68 ± 1.34 |
| F7 | 68.12 ± 5.87 | 0.42 ± 0.05 | 94.56 ± 3.81 | 9.61 ± 1.12 |
| F8 | 65.43 ± 5.13 | 0.39 ± 0.04 | 101.41 ± 3.14 | 12.91 ± 0.94 |
| F9 | 66.98 ± 6.09 | 0.38 ± 0.02 | 96.47 ± 1.47 | 13.67 ± 1.29 |
Values are expressed as mean ± SD; $n = 6, &n = 10.
*
Equilibrium moisture uptake (after 3 days).