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. 2020 Jan 28;10(1):101–112. doi: 10.1016/j.jcmgh.2020.01.009

Figure 3.

Figure 3

CD74 promotes mucosal healing in amebic colitis. (A and B) Increased CD74 protein expression in epithelial cells in human amebic colitis. Immunohistochemical analysis of CD74 expression in mucosa of patients with amebic colitis and normal healthy controls (n = 3 and 6, respectively). (C–E) H&E-stained images and histology scores of WT control and CD74–/– mice after infection with E histolytica. Intestinal permeability measured by albumin levels in cecal luminal contents (n = 7 per group). (F and G) H&E-stained images, histology scores, and albumin levels in WT mice treated with anti-CD74 or control antibodies (n = 8 per group). Scale bars: 200 μm. Data represent means and SD. *P < .05, **P < .01, ***P < .001.