Figure 1.

Regularized network showing the conditional dependence relations among the baseline depression symptoms (circles) and first-onset MDD (FO-MDD) during the 6 year follow-up period (yes or no; square). Edges represent conditional dependence relations among the variables and capture unique effects that remain after controlling for all the other variables in the network. The thickness and color saturation of the edges corresponds to the strength of the association. In this network, all associations are positive. The five symptom nodes that are directly predictive of first-onset MDD are indicated by thicker outlined circles. Abbreviations: agi = psychomotor agitation; app = appetite change; con = concentration problems; dep = depressed mood; dis = difficulty initiating sleep; dms = difficulty maintaining sleep; ene = fatigue or loss of energy; ema = early morning awakenings; FO-MDD = first-onset depression; gui = feelings of guilt or worthlessness; hyp = hypersomnia; int = loss of interest; ret = psychomotor retardation; sui = suicidal thoughts; wei = weight change.