Figure 4.

Examples of data from circadian wheel-running experiments. Examples of data obtained from wheel running experiments utilized to estimate circadian period among the DO mice, including scenarios where the period was and was not able to be estimated. Each row represents a double-plotted day of wheel running activity, used to estimate circadian period. Panels on the left illustrate animals with valid estimates of the circadian period either <24 h (top left), =24 h (middle left), or > 24 h (bottom left). Panels on the right illustrate scenarios where we are unable to estimate the circadian period due to non-consolidated activity (top right), lack of sufficient wheel running (middle right), or a combination of both factors (bottom right). These plots illustrate the broad diversity in the circadian period and wheel-running behavior in the DO mouse population.