Figure 6.
Heritability of observed and normalized phenotypes in founder strains and DO mice. The estimated broad-sense (H2) and narrow-sense (h2) heritability of measured phenotypes within the founder and DO mice are illustrated for traits on both the observed (top panel) and rank-based inverse normal transformed (bottom panel) scales. Heritability estimates with 95% CIs that did not include 0 were considered significant and are shown in black (hollow bars for H2 or solid bars for h2), while estimates where the CI included 0 are considered non-significant and presented in gray. Overall, considerably larger estimates of heritability were observed within the founder mice compared to the DO mice. This difference in broad-sense (within founders) and narrow-sense (within DO mice) heritability likely reflects the importance of non-additive genetic effects in determining the variability in measured sleep and circadian traits.