Table 1.

Comparisons of sleep architecture phenotypes in founder strains and DO mice

Measure*	Diversity Outbred	Founder strains
		129/SvlmJ	C57BL/6J	A/J	NOD/LtJ	NZO/H1LtJ	CAST/EiJ	PWK/PhJ	WSB/EiJ	ANOVA P-value†
Number of sleep bouts
24 h	234.0 ± 53.4	308.5 ± 26.3	230.6 ± 40.8	234.0± 31.0	242.4 ± 27.0	277.9 ± 24.1	188.8 ± 34.3	229.9 ± 32.3	210.8 ± 46.8	2.58 × 10−6
Lights-on	117.4± 29.5	139.3 ± 16.1	115.2 ± 18.6	130.4 ± 9.8	130.3 ± 14.8	137.8 ± 15.2	118.6 ± 21.0	139.2 ± 14.9	128.5 ± 15.2	0.0148
Lights off	116.9 ± 34.0	169.6 ± 12.1	115.6 ± 25.6	103.7 ± 28.2	112.4 ± 15.6	140.2 ± 11.7	70.2 ± 21.6	91.0 ± 33.6	82.3 ± 37.6	3.38 × 10−8
Average sleep bout duration (min)
24 h	3.70 ± 1.28	3.26 ± 0.30	3.42 ± 0.59	3.40 ± 0.38	2.92 ± 0.30	3.15 ± 0.35	3.03 ± 0.37	3.60 ± 0.75	3.41 ± 0.47	0.1749
Lights-on	5.16 ± 3.59	4.34 ± 0.75	4.69 ± 0.84	3.94 ± 0.28	3.97 ± 0.48	3.45 ± 0.54	3.31 ± 0.48	3.88 ± 0.89	4.01 ± 0.50	0.0011
Lights-off	2.77 ± 0.88	2.51 ± 0.27	2.25 ± 0.44	2.81 ± 0.52	1.75 ± 0.23	2.91 ± 0.23	2.60 ± 0.43	3.29 ± 0.96	2.61 ± 0.72	0.0001
Average wake bout duration (min)
24 h	2.99 ± 1.15	1.47 ± 0.20	3.09 ± 0.74	2.96 ± 0.59	3.11 ± 0.53	2.09 ± 0.18	4.92 ± 1.20	2.90 ± 1.21	3.75 ± 1.10	5.22 × 10−8
Lights-on	2.07 ± 0.81	1.10 ± 0.08	1.94 ± 0.61	1.64 ± 0.21	1.71 ± 0.27	1.89 ± 0.16	3.02 ± 1.22	1.57 ± 0.50	1.73 ± 0.47	3.00 × 10−5
Lights-off	4.54 ± 6.46	1.77 ± 0.31	4.36 ± 1.33	5.22 ± 2.00	4.88 ± 1.06	2.32 ± 0.28	8.95 ± 2.93	6.02 ± 4.24	8.18 ± 4.91	2.27 × 10−5

*Data presented as mean ± standard deviation.

^† p-Value from analysis of variance (ANOVA) comparing values across founder strains.