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. 2020 Apr 16;21(8):2774. doi: 10.3390/ijms21082774

Figure 1.

Figure 1

Non-coding RNAs involved in lung cancer initiation and progression along with the hallmark they affect. ↑, upregulation; ↓, downregulation; →, promotion; ┤, inhibition. Abbreviations: Apoptotic peptidase activating factor 1/2 (APAF1/2), BCL-2-like protein 11 (BIM), bromodomain-containing protein 4 (BRD4), cyclin E1 (CCNE1), E-cadherin (CDH1), cyclin dependent kinase 4 (CDK4), cyclin dependent kinase inhibitor 1A (CDKN1A), C-X-C motif chemokine receptor 4 (CXCR4), endoribonuclease Dicer (DICER), epidermal growth factor receptor (EGFR), endothelial PAS domain protein 1 (EPAS1), Erb-B2 receptor tyrosine kinase 4 (ERBB4), enhance of zeste 2 polycomb repressive complex 2 subunit (EZH2), F-box and WD repeat domain containing 7 (FBXW7), forkhead box O3 (FOXO3A), hypoxia inducible factor 1 alpha (HIF-1α), homeobox A3 (HOXA3), homeobox A5 (HOXA5), inhibitor of DNA binding 1 (ID1), interferon regulatory factor 2 (IRF2), Jumonji and AT-rich interaction (JARID2), minichromosome maintenance complex component 7 (MCM7), methyltransferase like 3 (METTL3), SMAD Family Member 3 (SMAD3), mechanistic target of rapamycin kinase (mTOR), metallothionein 1G (MT1G), protein tyrosine phosphatase receptor type U (PTPRU), programmed cell death 1 ligand 1 (PD-L1), programmed cell death 4 (PDCD4), phosphatidylinositol-3-kinase regulatory subunit 3 (PIK3R3), phosphatase and tensin homolog (PTEN), protein kinase C epsilon (PKC-ε), tumor necrosis factor ligand superfamily member 11 (RANKL), Ras p21 protein activator (RASA1), retinoblastoma-like protein 2 (RBL2), succinate dehydrogenase (SDH), sprouty related EVH1 domain containing 1/2 (SPRED1/2), sprouty 1 (SPRY1/3/4), SRC proto-oncogene non-receptor tyrosine kinase (SRC), signal transducer and activator of transcription 3 (STAT3), SUZ12 polycomb repressive complex 2 subunit (SUZ12), Simian virus 40 small T antigen (SV40 ST), transforming growth factor beta 1 (TGFβ), tissue inhibitor of metalloproteinases 2 (TIMP2), tumor protein 21 (TP21), tumor protein 53 (TP53), telomerase reverse transcriptase (TERT), vascular endothelial growth factor A (VEGFA), von Hipper-Lindau tumor suppressor (VHL), yes associated protein 1/tafazzin (YAP1/TAZ), Y-Box binding protein 1 (YBX1), zinc finger protein X-linked (ZFX).