Table 3.
Non-coding RNAs that affect cell signaling and metabolic pathways.
| Name of ncRNA | Type of ncRNA | Targets | Signaling Pathway | Metabolic Pathway | References |
|---|---|---|---|---|---|
| miR-21 | miRNA | PTEN | Ras/Raf/MEK/ERK, PI3K/Akt/mTOR | Glycolysis, Glucose-mediated TCA Cycle | [101] |
| miR-147b | miRNA | VHL, SDH | EGFR | ETC, TCA Cycle | [102] |
| miR-34a | miRNA | EGFR | Ras/Raf/MEK/ERK, PI3K/Akt/mTOR | Glycolysis | [199] |
| miR-329 | miRNA | MET | Ras/Raf/MEK/ERK, PI3K/Akt/mTOR | N.A. | [200] |
| miR-139-5p | miRNA | MET | Ras/Raf/MEK/ERK, PI3K/Akt/mTOR | N.A. | [201] |
| miR-206 | miRNA | MET | Ras/Raf/MEK/ERK, PI3K/Akt/mTOR | N.A. | [202] |
| miR-148a-3p | miRNA | SOS2 | Ras/Raf/MEK/ERK | N.A. | [203] |
| miR-193a-3p | miRNA | KRAS | Ras/Raf/MEK/ERK | N.A. | [204,205] |
| miR-181a-5p | miRNA | KRAS | Ras/Raf/MEK/ERK | N.A. | [206] |
| miR-30c | miRNA | BID, NF1 | Ras/Raf/MEK/ERK | Glucose-mediated TCA Cycle | [207] |
| Orilnc1 | lncRNA | N.A. | Ras/Raf/MEK/ERK | N.A. | [208] |
| miR-494-3p | miRNA | PTEN | PI3K/Akt/mTOR | Glycolysis | [85] |
| miR-19a | miRNA | MET | PI3K/Akt/mTOR | N.A. | [209] |
| miR-409-3p | miRNA | MET | PI3K/Akt/mTOR | N.A. | [210] |
| ROR | lncRNA | N.A. | PI3K/Akt/mTOR | Glycolysis | [211] |
| miR-142-3p | miRNA | HMGB1 | PI3K/Akt/mTOR | Glycolysis | [212] |
| miR-221 | miRNA | PTEN | PI3K/Akt/mTOR | Glycolysis | [213] |
| miR-124 | miRNA | GLUT1, HK2 | PI3K/Akt/mTOR | Glycolysis | [214] |
| miR-182 | miRNA | HIF1AN | PI3K/Akt/mTOR | ETC, TCA Cycle | [215] |
| lncRNA-NEF | lncRNA | GLUT1 | PI3K/Akt/mTOR | Glycolysis | [216] |
| miR-145-3p | miRNA | PDK1 | PI3K/Akt/mTOR | N.A. | [217] |
| miR-487b | miRNA | KRAS, Wnt5a, MYC | Wnt/β-Catenin | N.A. | [218] |
| miR-203 | miRNA | FZD2 | Wnt/β-Catenin | N.A. | [219] |
| miR-548b | miRNA | CCNB1 | Wnt/β-Catenin | N.A. | [220] |
| miR-374a | miRNA | Wnt5a | Wnt/β-Catenin | N.A. | [220] |
| AK126698 | lncRNA | FZD8 | Wnt/β-Catenin | ETC | [221] |
| LINC00673-v4 | lncRNA | DDX3 | Wnt/β-Catenin | N.A. | [222] |
| miR-660 | miRNA | MDM2 | p53 | N.A. | [223] |
| miR-98miR-453 | miRNA | TP53 | p53 | N.A. | [224] |
| circ-MTO1 | circRNA | miR-17 ┤QKI-5 | Notch | N.A. | [225] |
| circRNA_103809 | circRNA | miR-4302 ┤ZN121 | MYC | N.A. | [140] |
| miR-342-3p | miRNA | E2F1 | MYC | N.A. | [226] |
| miR-451a | miRNA | MYC | MYC | N.A. | [227] |
| PART1 | lncRNA | miR-635 | JAK/STAT | N.A. | [228] |
| miR-135 | miRNA | TRIM16 | JAK/STAT | N.A. | [229] |
┤, inhibition. Abbreviations: AKT serine/threonine kinase (AKT), BH3-interacting domain death agonist (BID), C-X3-C motif chemokine receptor 1 (CX3CR1), DEAD-box helicase 3 X-linked (DDX3), epidermal growth factor receptor (EGFR), E2F transcription factor 1 (E2F1), electron transport chain (ETC), frizzled class receptor 2 (FZD2), frizzled class receptor 8 (FZD8), glucose transporter 1 (GLUT1), hypoxia inducible factor 1 subunit alpha inhibitor (HIF1AN), high mobility group box 1 (HMGB1), janus kinase (JAK), mouse double minute 2 (MDM2), mechanistic target of rapamycin kinase (mTOR), neurofibromin 1 (NF1), prostate androgen-regulated transcript 1 (PART1), phosphoinositide-dependent protein kinase-1 (PDK1), phosphatase and tensin homolog (PTEN), quaking homolog (QKI-5), sirtuin 1 (SIRT1), son of sevenless homolog 2 (SOS2), signal transducer and activator of transcription (STAT), tricarboxylic acid cycle (TCA Cycle), tumor protein p53 (TP53), Wnt family member 5a (Wnt5a), wingless-type (WNT), not available (N.A.).