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. 2020 Apr 14;21(8):2712. doi: 10.3390/ijms21082712

Figure 1.

Figure 1

Stages of Progressing Nonproliferative Diabetic Retinopathy (NPDR). (A) Fundus photograph of a retina with no retinopathy observed during the first 10 years of diabetes. (B) In Mild NPDR, the first detectible sign of disease consists of a single microaneurysm (arrow, inset). (C) In moderate NPDR, retinal hemorrhages and hard exudates (circled) may be observed. (D) In severe NPDR, >20 intraretinal hemorrhages may be observed throughout the retina. Venous beading and intraretinal microvascular anomalies (IRMA) may be also seen (arrows).