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Life cycle of filaggrin. Filaggrin exists as profilaggrin within keratohyaline granules in the granular layer of the epidermis. Profilaggrin is degraded to form filaggrin during the terminal differentiation process. Then, in the upper part of the stratum corneum (SC), filaggrin is degraded into amino acids and plays a crucial role in maintaining SC hydration and pH by forming natural moisturizing factors, including pyrrolidine carboxylic acid (PCA) and urocanic acid (UCA).
