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. 2020 Apr 20;21(8):2867. doi: 10.3390/ijms21082867

Figure 4.

Figure 4

Thymic stromal lymphopoietin (TSLP) initiates the innate and adaptive phases of allergic immune responses in the skin. TSLP induces the maturation of dendritic cells to express OX40L, which in turn differentiates naive CD4+ T cells into Th2 cells to produce Th2 cytokines such as IL-4, IL-5, and IL-13, leading to the secretion of IgE from B cells. Together with the activation of Group 2 innate lymphoid cells (ILC2s), TSLP initiates the innate and adaptive immune responses of atopic dermatitis. Dieckol and phloxine O reduce atopic dermatitis-like inflammatory symptoms by inhibiting TSLP production.