Table 1.
Classification of ILC subsets.
| Cell Type | Cytokines Required for Development | Transcription Factors | Stimulating Cytokines | Cytokine Production | Biological Function | |
|---|---|---|---|---|---|---|
| Group 1 ILCs | NK cell | IL-15 | T-bet EOMES |
IL-12 IL-18 |
IFN-γ TNF |
Immunity to virus and cancer Chronic inflammation |
| ILC1 | IL-7 IL-15 |
T-bet | IL-12 IL-18 |
IFN-γ TNF |
Immunity to intracellular bacteria and protozoa Chronic inflammation |
|
| Group 2 ILCs | ILC2 | IL-7 | BCL11B GFI1 EST1 GATA3 |
IL-25 IL-33 TSLP |
IL-4 (in humans) IL-5 IL-13 AREG |
Immunity to helminths Asthma and allergic disease Metabolic homeostasis |
| Group 3 ILCs | LTi cell | IL-7 | RORγt | IL-23 IL-1β |
IL-17A/IL-17F IL-22 |
Lymphoid tissue developments Intestinal homeostasis Immunity to extracellular bacteria Chronic inflammation |
| NCR- ILC3 | IL-7 | AHR RORγt |
IL-23 IL-1β |
IL-17A/IL-17F IL-22 |
||
| NCR+ ILC3 | IL-7 | AHR RORγt T-bet |
IL-23 IL-1β |
IL-22 | ||