Skip to main content
. 2020 Apr 23;21(8):2980. doi: 10.3390/ijms21082980

Table 1.

The comparison of major morphological and biochemical features and markers of apoptosis and non-apoptotic cell death modalities [12,13,14,15].

Apoptosis Autophagy Necroptosis Ferroptosis Pyroptosis
morphology membrane blebbing formation of intracellular vesicles cell swelling shrunken mitochondria with reduced crista cell swelling; pore formation
DNA fragmentation + - +
(random)
- +
caspase activation + - - - +
positive staining with Annexin-V + - + + +
inflammation - - + + +
other typical features PARP cleavage LC3-I to LC3-II conversion; p62/SQSTM1 degradation RIPK3/MLKL activation; drop in ATP level iron accumulation and lipid peroxidation osmotic lysis of cell