Table 1.
Summary of the main recent findings of pharmacogenomic studies in childhood asthma.
| rsID/ Chr. Band |
Chr:Position a | Gene/ Nearest Gene |
Effect Allele | Effect | p-Value | Reference |
|---|---|---|---|---|---|---|
| SABA response | ||||||
| rs73650726 | 9:85152666 | 9q21 | A | β = −3.8 | 7.69 × 10−9 | [26] |
| rs7903366 | 10:53689774 | PRKG1 | T | β = 1.23 | 3.94 × 10−8 | |
| rs7070958 | 10:53691116 | PRKG1 | A | β = −1.24 | 4.09 × 10−8 | |
| rs7081864 | 10:53690331 | PRKG1 | A | β = 1.23 | 4.94 × 10−8 | |
| rs17834628 | 5:12978566 | LINC01194, LINC02220, DNAH5 | A | OR = 1.67 | 1.18 × 10−8 | |
| rs35661809 | 5:12968341 | LINC01194, LINC02220, DNAH5 | G | OR = 1.59 | 3.33 × 10−8 | |
| 1p13.2 | 1:114177000-1:114178000 | MAGI3, PHTF1, RSBN1 | NA | NA | 4.40 × 10−9 | [25] |
| 11p14.1 | 11:27507000-11:27508000 | LOC105376671, LGR4, LIN7C | NA | NA | 6.59 × 10−9 | |
| 19p13.2 | 19:10424000-19:10425000 | ZGLP1, ICAM5, FDX1L, RAVER1 | NA | NA | 3.12 × 10−11 | |
| 4q13.3 | 4:73478000-4:73479000 | ADAMTS3, COX18 | NA | NA | 6.25 × 10−8 | |
| 8q22.1 | 8:97926000-8:97927000 | SDC2, CPQ, LOC101927066, TSPYL5 | NA | NA | 1.32 × 10−7 | |
| ICS response | ||||||
| rs5995653 | 22:39404249 | APOBEC3B-APOBEC3C | A | OR = 0.70 | 3.31 × 10−7 | [27] |
| rs62081416 | 18:6605442 | L3MBTL4-ARHGAP28 | A | OR = 2.44 | 1.57 × 10−5 | |
a Position based on GRCh37/hg19 build. rsID: reference SNP cluster ID; Chr: chromosome; SABA: short-acting beta agonist; ICS: inhaled corticosteroid; OR: odds ratio; NA: not available.