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. 2020 Apr 17;21(8):2802. doi: 10.3390/ijms21082802

Figure 2.

Figure 2

Modeling KCNA1 mutations associated with epilepsy. (A) Model of a Kv1.1–Kv1.2 heterotetramer built using a homology model of human Kv1.1 (blue) and human Kv1.2 (orange), which were made with SWISS-MODEL [92] using the crystal structure of rat Kv1.2 (RCSB PDB: 3LUT) [74]. Human Kv1.1 and Kv1.2 share 80% and 99.4% sequence identity with rat Kv1.2, respectively. One Kv1.1 subunit is shown in ribbons, with epilepsy-associated mutations shown in van der Waals (vdW) representation colored magenta, and other subunits shown in vdW representation. (B) Homology model of a single Kv1.1 subunit with epilepsy-associated mutations shown in magenta in vdW representation. (C) Two-dimensional representation of a human Kv1.1 subunit. Magenta circles represent mutations associated with epilepsy; blue circles are conserved gating charges in the voltage-sensing domain. The highly conserved PVP motif is noted in purple.