Table 2.

Rodent models of Kcna1 mutations and their associated phenotypes.

Species	Mutation	Phenotype	Reference
Mouse	V408A/+	Stress-induced motor incoordination, acetazolamide responsive	[96]
Mouse	Truncation at aa 230	Epilepsy, megalencephaly, unsteady gait	[98,99,100]
Mouse	Global gene knockout	Epilepsy, sleep deficits, cardiorespiratory abnormalities, sudden death	[72,73,101,102,103,104,105]
Mouse	Neuron-specific conditional gene knockout	Epilepsy, cardiorespiratory abnormalities, sudden death	[106]
Rat	S309T	Myokymia, neuromyotonia, seizures, premature death	[107]

Animal models of Kcna1 dysfunction were identified through PubMed literature searches. Information was pooled from multiple sources, when applicable, to generate the summarized data presented in the table.