Table 1.
Area under the curve (AUC) values and viral score (VS) for different pathogens and studies. Figures in round brackets show the CI95% (calculated using 2000 bootstrap replicates). No expression (NE) means that at least one of the transcripts of the signature was not expressed. CC: Chinese group; SC: Spanish group; VZF: Varicella Zoster infected fibroblasts; MNC: mononuclear cells with dengue, EC: human umbilical vein endothelial cells enterovirus group, MC: Mexican group.
| Database | Comparison | n | AUC | Sensitivity | Specificity | VS | |
|---|---|---|---|---|---|---|---|
| 2-LncRNA | |||||||
| CC | PRJNA230906 | virus vs. control | 4 | 1 (1–1) | 1 | 1 | 2.569 |
| MNC | GSE98859 | virus vs. control | 5 | 1 (1–1) | 1 | 1 | 4.939 |
| EC | GSE94551 | virus vs. control | 6 | 1 (1–1) | 1 | 1 | 4.043 |
| SC | PRJNA325575 | virus vs. control | 18 | 1 (1–1) | 1 | 1 | 7.535 |
| MC | GSE69529 | virus vs. control | 115 | 0.891 (0.833–0.950) | 0.857 | 0.838 | 8.350 |
| MC | GSE69529 | virus vs. bacteria | 220 | 0.731 (0.662–0.800) | 0.814 | 0.600 | 8.113 |
| MC | GSE69529 | bacteria vs. control | 175 | 0.707 (0.621–0.793) | 0.650 | 0.743 | 8.392 |
| VZF | GSE121385 | virus vs. control | 6 | 1 (1–1) | 1 | 1 | 15.015 |
| 2-LncRNA + IFI44L | |||||||
| CC | PRJNA230906 | virus vs. control | 4 | 1 (1–1) | 1 | 1 | 1.980 |
| MNC | GSE98859 | virus vs. control | 5 | 1 (1–1) | 1 | 1 | 2.596 |
| EC | GSE94551 | virus vs. control | NE | NE | NE | NE | NE |
| SC | PRJNA325575 | virus vs. control | 18 | 1 (1–1) | 1 | 1 | 3.227 |
| MC | GSE69529 | virus vs. control | 115 | 0.857 (0.784–0.929) | 0.800 | 0.850 | 6.133 |
| MC | GSE69529 | virus vs. bacteria | 220 | 0.724 (0.651–0.797) | 0.855 | 0.525 | 4.101 |
| MC | GSE69529 | bacteria vs. control | 175 | 0.723 (0.623–0.824) | 0.790 | 0.714 | 6.883 |
| VZF | GSE121385 | virus vs. control | 6 | 1 (1–1) | 1 | 1 | 9.670 |
| 2-LncRNA + IFI44L + FAM89A | |||||||
| CC | PRJNA230906 | virus vs. control | 4 | 1 (1–1) | 1 | 1 | 2.328 |
| MNC | GSE98859 | virus vs. control | 5 | 1 (1–1) | 1 | 1 | 4.899 |
| EC | GSE94551 | virus vs. control | NE | NE | NE | NE | NE |
| SC | PRJNA325575 | virus vs. control | 18 | 1 (1–1) | 1 | 1 | 11.640 |
| MC | GSE69529 | virus vs. control | 115 | 0.850 (0.774–0.927) | 0.800 | 0.863 | 8.247 |
| MC | GSE69529 | virus vs. bacteria | 220 | 0.753 (0.684–0.822) | 0.630 | 0.788 | 7.469 |
| MC | GSE69529 | bacteria vs. control | 175 | 0.681 (0.579–0.783) | 0.710 | 0.714 | 8.773 |
| VZF | GSE121385 | virus vs. control | 6 | 1 (1–1) | 1 | 1 | 9.679 |
| FAM89A + IFI44L | |||||||
| CC | PRJNA230906 | virus vs. control | 4 | 1 (1–1) | 1 | 1 | −2.650 |
| MNC | GSE98859 | virus vs. control | 5 | 0.625 (0.500–0.875) | 1 | 0.250 | −0.091 |
| EC | GSE94551 | virus vs. control | NE | NE | NE | NE | NE |
| SC | PRJNA325575 | virus vs. control | 18 | 1 (1–1) | 1 | 1 | 4.715 |
| MC | GSE69529 | virus vs. control | 115 | 0.829 (0.749–0.910) | 0.771 | 0.825 | −3.764 |
| MC | GSE69529 | virus vs. bacteria | 220 | 0.745 (0.674–0.816) | 0.813 | 0.638 | −4.834 |
| MC | GSE69529 | bacteria vs. control | 175 | 0.647 (0.544–0.749) | 0.748 | 0.629 | −2.924 |
| VZF | GSE121385 | virus vs. control | 6 | 1 (1–1) | 1 | 1 | −2.270 |