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. 2020 Apr 11;21(8):2663. doi: 10.3390/ijms21082663

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Structures of hepsin, matriptase and transmembrane protease serine (TMPRSS) 2 are shown. All type II transmembrane serine proteases (TTSPs) show single-pass transmembrane proteins with intracellular NH2-terminus and extracellular carboxy-terminal serine protease domains. Hepsin is composed of scavenger receptor (SR) and serine protease domains. Matriptase contains sea urchin sperm protein/enteropeptidase/agrin (SEA) domain, Cls/Cls, urchin embryonic growth factor, bone morphologic protein-1 (CUB) domain, four low-density lipoprotein receptor (L) domains class A and serine protease domains. TMPRSS2 is consists of an L domain, SR, and serine protease domains.