Table 2.

Genetic variants affecting genes involved in the liver response to drugs.

Group	Gene	Variants	Drugs Affected	Consequences	References
Cholesterol lowering drugs	HMGCR	rs17244841	Pravastatin	Reduced response	[112]
		rs17238540
		rs17671591	Atorvastatin	Increased response	[113]
	APOE	rs7412	Simvastatin, Pravastatin, Atorvastatin	Increased response	[114,115,116]
		rs449647	Lovastatin, Bezafibrate	Altered response	[117]
	LDLR	rs2738466	Pravastatin	Increased response	[118]
		rs1433099
	CETP	rs1532624	Statins	Reduced response	[119]
Antidiabetic drugs	ATM	rs11212617	Metformin	Reduced response	[120,121]
	IRS1	rs1801278	Sulfonylureas, Metformin	Reduced response	[122]
	PPARG	rs1801282	Pioglitazone	Increased response	[123]
Anticoagulant drugs	VKORC1	rs9923231	Warfarin	Increased response Toxicity	[124,125]
		rs9934438
		rs8050894
		rs2884737
		rs7294	Warfarin	Reduced response	[126,127]
		rs61742245
		rs2359612
		rs17708472
Anticancer drugs	KDR	rs1870377	Sorafenib	Reduced response Toxicity	[128,129]
		rs2305948	Sorafenib	Increased response	[128]
		rs2071559	Sorafenib	Reduced response	[128]
	VEGFA	rs2010963	Sorafenib	Reduced response	[130]
	VEGFC	rs4604006	Sorafenib	Reduced response	[130]
	eNOS3	rs2070744	Sorafenib	Reduced response	[131]
	ANGPT2	rs55633437	Sorafenib	Reduced response	[131]
	HIF1A	rs12434438	Sorafenib	Increased response	[132]
	ERCC1	rs11615	Gemcitabine, Cisplatin	Increased response	[133]
	SLC31A1	rs12686377	Platinum derivatives	Impaired response	[133]
	IDH1	rs121913499	Ivosidenib	Increased response	[134]
		rs121913500