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Proposed model of HSP70’s impact on Th cell fate. In conditions of stress, HSP70 is activated and forms a complex with AGO2. This complex has a different propensity for miRNA processing, which under the TCR stimulation by a cognate antigen presented by APC, promotes generation of pro-Th17 miRNA. As a result, the Th cell turns into pathogenic Th17 with a capacity to initiate autoaggression.
