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. 2020 Apr 17;17(8):2787. doi: 10.3390/ijerph17082787

Table 1.

Classification of anaphylaxis severity [12].

Classification by Mueller
Grade I Generalized urticaria, itching, malaise, and anxiety
Grade II Any of the above plus two or more of the following: angioedema, chest constriction, nausea, vomiting, diarrhoea, abdominal pain, dizziness
Grade III Any of the above plus two or more of the following: dyspnoea, wheezing, stridor, dysarthria, hoarseness, weakness, confusion, feeling of impending disaster
Grade IV Any of the above plus two or more of the following: fall in blood pressure, collapse, loss of consciousness, incontinence, cyanosis
Classification by Ring and Messmer
Grade I Generalized skin symptoms (e.g., flush, generalized urticaria, angioedema)
Grade II Mild to moderate pulmonary, cardiovascular, and/or gastrointestinal symptoms
Grade III Anaphylactic shock, loss of consciousness
Grade IV Cardiac arrest, apnoea