AD |
Alzheimer’s Disease |
PD |
Parkinson’s Disease |
HD |
Huntington Disease |
ALS |
Amyotrophic Lateral Sclerosis |
FTD |
Frontotemporal Dementia |
MSA |
Multiple System Atrophy |
α-syn |
Alpha-Synuclein |
Aβ |
Amyloid-Beta |
AβPP |
Amyloid-Beta Precursor Protein |
TDP-43 |
Tar-DNA-Binding Protein of 43 KDa |
SOD |
Cu/Zn Superoxide Dismutase |
FUS |
Fused In Sarcoma |
UPS |
Ubiquitin Proteasome System |
UBQLNs |
Ubiquilin Proteins |
HDAC6 |
Histone Deacetylase 6 |
UBA |
Ubiquitin-Associated |
UBL |
Ubiquitin-Ligated |
UBA6 |
Ubiquitin-Activating Enzyme (E1) |
BIRC6 |
Hybrid Ubiquitin-Conjugating Enzyme/Ubiquitin-Ligase (E2/E3) |
GABARAP |
GABA Type A Receptor-Associated Protein |
METH |
Methamphetamine |
mTOR |
Mammalian/Mechanistic Target Of Rapamycin |
TFEB |
Transcription Factor EB |
FBXO7 |
F-box only protein 7 |
LAMP1 |
Lysosomal-Associated Membrane Protein 1 |
LC3 |
Microtubule-Associated Protein 1a/1b-Light Chain 3 |
HERC1 |
HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase Family Member 1 |
HSPA8 |
Heat Shock Protein Family A (Hsp70) Member 8 |
HSPA1A |
Heat Shock Protein Family A (Hsp70) Member 1A |
BAG1/3 |
Bcl2-Associated Athanogene 1/3 |
DLB |
Dementia with Lewy Bodies |
PSP |
Progressive Supranuclear Palsy |
MPTP |
1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine |
6-OHDA |
6-Hydroxydopamine |
3-MA |
3-Methyladenine |
USP9X |
Ubiquitin Specific Peptidase 9 X-Linked |
APP |
Amyloid Precursor Protein |
GSK3β |
Glycogen Synthase Kinase3 Beta |
BACE2 |
Beta-Secretase 2 |
POLDIP2 |
DNA Polymerase Delta Interacting Protein 2 |
NUB1 |
Negative Regulator of Ubiquitin-Like Protein 1 |
USP14 |
Ubiquitin Specific Peptidase 14 |
HSC70 |
Heat Shock Cognate 71 Kda Protein (Hsc70), also known as HSPA8 |
EVs |
Extracellular Vesicles |
CSF |
Cerebrospinal Fluid |
CNS |
Central Nervous System |
AGEs |
Advanced Glycation End Products |
RAGEs |
Receptors for Advanced Glycation End Products |
PKC |
Protein Kinase C |
NF-kB |
Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells |
JAK2/STAT1 |
Janus Kinase 2/Signal Transducer and Activator of Transcription 1 |
Ag |
Antigen |
MHC-I |
Major Histocompatibility Complex Type I |
MHC-II |
Major Histocompatibility Complex Type II |
CD8+ T-cells |
CD8 positive Cytotoxic T Lymphocytes |
CD4+ Th cells |
CD4 positive T Helper Lymphocytes |
TLR4 |
Toll-Like Receptor 4 |
ULK1 |
Unc-51-Like Autophagy-Activating Kinase 1 |