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. 2020 Apr 17;21(8):2820. doi: 10.3390/ijms21082820

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Assessment of changes in neuronal density, microglial/astrocyte activity, and amyloid burden of 5XVCI mice. (A) According to the Y-maze results, an impairment in spatial working memory was not observed from the 5XVCI mice. (B)According to NeuN immunostaining (green), a significant reduction in hippocampal neuronal density was observed from the 5XVCI group. * p < 0.05 vs.5X-Sham; mean ± S.E.M, scale bar = 20 μm. (C) Significant changes in microglia and astrocyte activities were not observed from the double immunostaining of Iba-1 (green) and GFAP (red) markers, respectively. Mean ± S.E.M, scale bar = 20 μm. (D) There was a significant reduction in 6E10 immunoreactivity in the hippocampi of 5XVCI mice compared to the 5X-Sham mice. * p <0.05 vs.5X-Sham; mean ± S.E.M, scale bar = 200 μm.

Assessment of changes in neuronal density, microglial/astrocyte activity, and amyloid burden of 5XVCI mice. (A) According to the Y-maze results, an impairment in spatial working memory was not observed from the 5XVCI mice. (B)According to NeuN immunostaining (green), a significant reduction in hippocampal neuronal density was observed from the 5XVCI group. * p < 0.05 vs.5X-Sham; mean ± S.E.M, scale bar = 20 μm. (C) Significant changes in microglia and astrocyte activities were not observed from the double immunostaining of Iba-1 (green) and GFAP (red) markers, respectively. Mean ± S.E.M, scale bar = 20 μm. (D) There was a significant reduction in 6E10 immunoreactivity in the hippocampi of 5XVCI mice compared to the 5X-Sham mice. * p <0.05 vs.5X-Sham; mean ± S.E.M, scale bar = 200 μm.