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. 2020 Apr 15;21(8):2726. doi: 10.3390/ijms21082726

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The specific activity of sucrase-isomaltase is reduced in BBM/P2 fractions. Caco-2 cells were treated or not treated with dextran sulfate sodium (DSS). The cellular homogenates were separated into intracellular+ basolateral membranes and brush-border membranes (BBM/P2) using CaCl₂. The specific activity of sucrase-isomaltase (SI) versus sucrose as a substrate in BBM/P2 fractions was measured. The results revealed a 3-fold approximate significant reduction of SI activity in DSS-treated Caco-2 cells in comparison to the control (Ctr) non-treated cells. Student’s t-test, *** p < 0.001, SEM, n = 3.