Table 1.
The MIC of β-lactam antibiotics and other class antibiotics against the multidrug-resistant Escherichia coli RC85+ and isogenic mutant strains of RC85+.
| Class | Antibiotics | MIC (μg/mL)a | |||
|---|---|---|---|---|---|
| RC85+ | Δblc1 | ΔompC | ΔompF | ||
| β-lactam antibiotics | Ampicillin | >1024 | 4 | >1024 | >1024 |
| Cefotaxime | >1024 | <1/2 | >1024 | >1024 | |
| Cefoperazone | 1024 | <1/2 | 1024 | >1024 | |
| Methicillin | >1024 | 256 | >1024 | >1024 | |
| Amoxicillin | >1024 | 2 | >1024 | >1024 | |
| Cefazolin | 1024 | 1 | >1024 | >1024 | |
| Cefalexin | 512 | 8 | 512 | 1024 | |
| Cloxacillin | >1024 | 128 | >1024 | >1024 | |
| Other class antibiotics | Streptomycin | >1024 | >1024 | >1024 | >1024 |
| Kanamycin | >1024 | >1024 | >1024 | >1024 | |
| Colistin | 4 | 4 | 4 | 4 | |
| Amikacin | 8 | 8 | 8 | 8 | |
| Nalidixic acid | >1024 | >1024 | >1024 | >1024 | |
a MIC indicates minimum inhibitory concentration.