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. 2020 Apr 23;21(8):2993. doi: 10.3390/ijms21082993

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Synergistic effect of the anti-cancer drug TMZ and the blood vessel inhibitor SU on U87 MCTSs on vascularized tissues. (A) Actin (red), DAPI (blue), and merged image of MCTSs on vascularized tissue treated with TMZ (500 μM), SU (50 μM), or TMZ (500 μM)/SU (50 μM) for 72 h. The scale bar represents 500 μm. (B) Diameter of the drug treated MCTSs. The data were obtained for 4–6 MCTSs on two different bioprinted layers for each drug treatment. Student’s t-test; * p < 0.05, ** p < 0.01, *** p < 0.001.