Table 1.

Summary of possible effects of CCGs on health

Name of CCG	Manifestation of the Disease
CLOCK	Hyperphagia, hyperlipidemia, hyperinsulinemic hyperglycemia, sleep disorders [26]
BMAL1	Induction of adipogenesis in adipocytes of adipose tissue, hypotension [27,28]
PPARγ	Reduction of circadian blood pressure oscillation [29]
CRY	Hypertension, aldosterone overproduction [30]
HDAC3	Disruption in lipid homeostasis of the liver and severe steatosis [31]
PER	Circadian period change, Advanced Sleep-Wake Phase Disorder (ASWPD), Delayed Sleep-Wake Phase Disorder (DSWPD) [23,32,33]
SIRT1	Regulation of adipocyte differentiation, gluconeogenesis and insulin secretion, changes in fat burning during sleep [34,35,36]