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↓Cystic fibrosis transmembrane conductance regulator (CFTR) → ↑ Wnt/β-catenin signaling → ↑ proliferation. CFTR deficiency leads to increased cellular response to Wnt/β-catenin signaling and cellular proliferation. For example, CFTR deficiency enhances survival of colon organoids from CFTR knockout (KO) mice [5]. Increases in Wnt/β-catenin signaling is a hallmark of colorectal cancer (CRC) development. Figure created using BioRender.com.
