Table 1.
White blood cell counts and numbers of spontaneously formed CFU-GM in 8 patients in whom in vitro cultures could be performed before and after transformation to secondary acute myeloid leukemia.
| Patient | Genotype | WBC G/L Pretransform. (%PB blasts) |
WBC G/L Posttransform. (%PB blasts) |
CFU–GM/105 MNC Pretransform. |
CFU-GM/105 MNC Posttransform. |
|---|---|---|---|---|---|
| UPN1-026 | CBL | 12.3 (2%) | 178 (60%) | 35 | 302 |
| PN1-033 | NRAS | 7.8 (4%) | 160 (10%) | 200 | 533 |
| UPN1-038 | NA | 93.8 (1%) | 50.7 (30%) | 622 | 4553 |
| UPN1-071 | PTPN11 | 74.0 (8%) | 161 (18%) | 11 | 48 |
| UPN1-128 | NRAS | 57.5 (3%) | 155 (13%) | 59 | 272 |
| UPN1-142 | NRAS | 20.3 (0%) | 80.7 (1%) | 48 | 202 |
| UPN1-171 | NRAS | 55.5 (0%) | 50.0 (54%) | 1 | 254 |
| UPN1-468 | NRAS | 8.5 (0%) | 24.5 (57%) | 8 | 381 |
NA—not available.