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. 2020 Apr 23;21(8):2979. doi: 10.3390/ijms21082979

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The knockdown of LINC00312 ablates myofibroblast features in fBMFs. (A) The silencing effect of LINC00312 in fBMFs was validated by qRT-PCR analysis. (B) The proliferation rate of sh-Luc or LINC00312-knockdown fBMFs was analyzed by an MTT assay. (C) The silencing of LINC00312 repressed the expression level of myofibroblast markers (α-SMA and p-Smad2), (D) collagen gel contraction, (E) transwell migration, and (F) wound healing abilities in two lines of patient-derived fBMFs with a lentiviral-mediated LINC00312 knockdown. Experiments were repeated three times and representative results were shown. Results were presented as means ± SD. * p < 0.05 compared with the sh-Luc control.