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. 2020 Apr 23;21(8):2979. doi: 10.3390/ijms21082979

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Downregulation of YBX1 in fBMFs diminishes the expression of fibrosis-associated markers and the myofibroblast activities. (A) Knockdown efficiency of YBX1 and the inhibited expression of fibrosis-associated markers (α-SMA and p-Smad2) were confirmed by Western blot following the silencing of YBX1. Downregulation of YBX1 in fBMFs repressed the myofibroblast activities, including collagen gen contractility (B), migration (C), and wound healing (D) capacities. Results are means ± SD of triplicate samples from three experiments. (E) The overexpression effect of LINC00312 in BMFs was validated by qRT-PCR analysis. * p < 0.05 compared to the Sh-Luc group.