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. 2020 Apr 15;21(8):2743. doi: 10.3390/ijms21082743

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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MicroRNA analysis of inflammatory and hypoxia associated microRNAs in circulating plasma-EVs of pre-motor PD and sham animals. (A) Significantly increased relative expression of the inflammatory miR21 was observed in plasma-EVs of the pre-motor PD rats, compared with shams. (B) Significantly increased relative expression of the inflammatory miR155 was observed in plasma-EVs of pre-motor PD rats, compared with shams. (C) The relative expression of the hypoxia related miR210 was significantly increased in plasma-EVs of pre-motor PD rats, compared with those of sham-treated animals. Results are represented as relative microRNA (miR) expression compared to the internal control miRs (2^Λ(-DDCT)); exact p-values are indicated, error bars show SD (n = 3 biological and three technical replicates for all; ctrl = sham; PD = pre-motor PD models).