Figure 9.

Illustration of SAS-/LAS-induced toxic effects in zebrafish embryos. AgNPs triggered size- as well as dose-dependent toxicity and accumulated in the embryos. The deposition of AgNPs increased the number of developmental defects and the induction of specific malformations. Mechanically, AgNPs activate various cellular toxic signaling pathways, including increased ROS, lysosomal activity and apoptosis. Interestingly, LAS showed different behavior from SAS. LAS increased the pore size and penetrated the chorion, resulting in an abundance of AgNP deposition.