Table 1.
Signaling pathways regulated by the interaction of macrophages with modified LDL and latex beads. Native LDL was excluded from the consideration because it does not cause lipid accumulation. Signaling pathways adjustable unidirectionally in all four types of modifications are highlighted in green; signaling pathways, the direction of regulation of which coincides with the three types of modifications are highlighted in cyan color; signaling pathways coinciding only in the case of two modifications are highlighted in yellow.
| Modification | Regulation | Signaling Pathway |
|---|---|---|
| Naturally Occurring | up | neurotrophic signaling TLR2-mediated signaling TLR9 pathway VEGF-A pathway |
| down |
Aurora-B cell cycle regulation
Cdc20 deubiquitination Cdc20 ubiquitination cyclinB1 ubiquitination ---> anaphase onset Fzr1 ---> cyclin B1 degradation Metaphase to Anaphase transition securin degradation Usp44 ---> Cdc20 |
|
| Desialylation | up | Apo2L pathway Fas pathway insulin ---> ERK neurotrophic signaling TLR9 pathway |
| down |
Aurora-B cell cycle regulation
Cdc20 deubiquitination Cdc20 ubiquitination cyclinB1 ubiquitination ---> anaphase onset Fzr1 ---> cyclin B1 degradation Metaphase to Anaphase transition securin degradation Usp44 ---> Cdc20 |
|
| Acetylation | up | alpha IIb beta3 ---> Rac1 alpha IIb beta3 pathway angiotensin II ---> DAG, CaMKII Aurora-A activation, substrates, and degradation Aurora-A cell cycle regulation B-cell antigen receptor pathway BCR ---> ERK BDNF ---trkB---> MAPK cascade beta-glucan ---> AKT-1 Fas pathway G-alpha-q ---> arachidonic acid, ERK insulin ---> ERK insulin pathway insulin ---Shc---> MAPK cascade KSR scaffold complex neurotensin pathway neurotrophic signaling p38 pathway p53 pathway PDGF A ---> ERK PDGF B ---> ERK PKC ---> ERK1, ERK2 POSH ---> JNK1, JNK2 PRL ---Src, FAK1---> ERK RANKL ---> p38 RANKL pathway Tiam1 ---> p38alpha TLR2 ---Rac1--->AKT TLR2-mediated signaling TLR3 pathway TLR9 pathway tuberin pathway VEGF-A pathway |
| down | Aurora-B cell cycle regulation | |
| Oxidation | up | AR pathway Fas pathway HIF-1alpha pathway IRAK-1 ---MKK3---> TNF p38 pathway p53 pathway PKC ---> ERK1, ERK2 RANKL ---> p38 RANKL pathway TLR2-mediated signaling TLR3 pathway TLR9 pathway |
| down | - |