Table 1.
LncRNAs related to renal fibrosis.
| LncRNA | Dysregulation | Related Disease/Experiment | Biological Role | Signal/Target Cell |
|---|---|---|---|---|
| Arid2-IR | Upregulation | UUO kidney | TGF-β/Smad3-associated renal fibrosis | NF-κB-dependent inflammation |
| CHCHD4P4 | Upregulation | Renal damage (fibrosis) | Epithelial-to mesenchymal transition | Tubular epithelial cell |
| CYP4B1-PS1-001 | Upregulation | Diabetic nephropathy | Regulation of fibrosis | Mesangial cell |
| ENSMUST00000147869 | Upregulation | Diabetic nephropathy | Decreased PCNA and cyclin D1 | Mesangial cell |
| Erbb4-IR | Upregulation | UUO kidney, diabetic nephropathy | Downregulation of Smad7 | TGF-β1/Smad3 signaling |
| H19 | Upregulation | UUO kidney | Downregulation of miR-17 expression | Tubular epithelial cell |
| HOTAIR | Upregulation | Acute kidney injury | Promotion of apoptosis | Notch1 pathway |
| LINC00936 | Downregulation | Chronic renal failure | Regulation of fibrosis | FoxO signaling |
| LncRNA-ATB | Upregulation | Acute rejection | Loss of kidney function | Activated by TGF-β1 |
| MALAT1 | Upregulation | Diabetic nephropathy | Translocation of β-catenin; SRSF1 overexpression | TGF-β1-mediated fibrosis |
| MIAT lncRNA | Upregulation | Diabetic nephropathy | Nrf2 regulation | Tubular epithelial cell |
| NEAT1 | Upregulation | Acute kidney disease, diabetic nephropathy | Proliferation of Mesangial cell | NF-κB pathway |
| PVT1 | Upregulation | Diabetic nephropathy | ECM accumulation | TGF-β1-mediated fibrosis |
| Rantes lncRNA | Upregulation | Acute kidney injury, ischemic reperfusion | Produced by HIF-1α | Tubular epithelial cell |
| TapSAKI | Upregulation | Acute kidney injury, hypoxia | Predictor of prognosis | Tubular epithelial cell |
| Tug1 | Upregulation | Diabetic nephropathy | Mitochondria-dependent mechanism | Podocyte |
| Xist | Upregulation | Glomerular disease | Urinary biomarker | Tubular epithelial and glomerular cell |