Table 1.
Composition of Akt isoforms in cells of various origins.
| Cell Type | Origin | Disease | Cat. No. | Akt1 (%) | Akt2 (%) | Akt3 (%) |
|---|---|---|---|---|---|---|
| SH-SY5Y | Bone marrow | Neuroblastoma | CRL-2266, ATCC | 40 ± 3 | 10 ± 1 | 50 ± 5 |
| HepG2 | Liver | Hepatocellular carcinoma | HB-8065, ATCC | 86 ± 4 | 14 ± 5 | 0 ± 0 |
| HMC3 | Brain, microglia | Neuroinflammation | CRL-3304, ATCC | 75 ± 7 | 12 ± 1 | 13 ± 1 |
| Jurkat | Peripheral blood | Acute T-cell leukemia | TIB-152, ATCC | 55 ± 6 | 45 ± 2 | 0 ± 0 |
| Caco-2 | Colon | Colorectal adenocarcinoma | HTB-37, ATCC | 46 ± 4 | 54 ± 5 | 0 ± 0 |
| A549 | Lung | Lung carcinoma | CCL-185, ATCC | 28 ± 2 | 57 ± 5 | 15 ± 1 |
| HEK293 | Kidney | Normal embryonic kidney | CRL-1573, ATCC | 37 ± 3 | 24 ± 2 | 39 ± 3 |
| MDA-MB-231 | Breast | Mammary adenocarcinoma | CRM-HTB-26, ATCC | 71 ± 6 | 11 ± 1 | 18 ± 2 |
| Pre-adipocytes | Subcutaneous adipose tissue | Obesity | SP-2006-3, Zen-Bio | 57 ± 5 | 23 ± 2 | 19 ± 2 |
| Adipocytes | Subcutaneous adipose tissue | Obesity | SA-1006-3, Zen-Bio | 58 ± 5 | 35 ± 3 | 7 ± 1 |