3R	Replacement, reduction, and refinement
αTC1.9	AlphaTC1 Clone 9
ADME	Absorption, distribution, metabolism and elimination
AO	Adverse outcome
AOP	Adverse outcome pathway
BMI	Body mass index
BPA	Bisphenol A
BPF	Bisphenol F
BPS	Bisphenol S
CYP450	Cytochrome P450
DDE	Dichlorodiphenyldichloroethylene
DEHP	Di-(2-ethylhexyl)phthalate
DG	Directorate-general
ED	Endocrine disruptor
ECHA	European chemical agency
EFSA	European food safety authority
EPAA	European partnership for alternative approaches to animal testing
EndoC-βH1	Human pancreatic β cell line EndoC-βH1
EU	European Union
GC-HRMS	Gas chromatography-high resolution mass spectrometry
HepaRG	Human hepatocellular carcinoma cell line HepaRG
HepG2	Human hepatocellular carcinoma cell line HepG2
hMADS	Human multipotent adipose-derived stem
IATA	Integrated approach for testing and assessment
IQ	Intelligence quotient
ITS	Integrated testing strategy
JRC	Joint Research Center
KE	Key event
KER	Key event relationship
LC-HRMS	Liquid chromatography-high resolution mass spectrometry
MIE	Molecular initiating event
MIHA	Immortalized Human Hepatocytes
MIN6	Mouse insulinoma 6
NAFLD	Non-alcoholic fatty liver disease
NMR	Nuclear magnetic resonance
NR	Nuclear receptor
NRC	National Research Center
OECD	Organization for economic co-operation and development
PBPK	Physiologically based pharmacokinetic
PK	Pharmacokinetic
PoT	Pathway of toxicity
PPARγ	Peroxisome proliferator-activated receptor gamma
qPCR	Quantitative polymerase chain reaction
QSAR	Quantitative structure activity relationships
REACH	Registration, evaluation and authorization of chemicals
SGBS	Simpson-Golabi-Behmel syndrome
US	United Sates
WAT	White adipose tissue
ZOT	Zebrafish obesogenic test