Skip to main content
. 2020 Apr 13;21(8):2703. doi: 10.3390/ijms21082703

Table 1.

NO donors and their effects on cytokines.

Drug Effect Reference
Nitrate esters Inhibition of NF-kappaB-regulated macrophage polarization shift [19]
SIN-1 Inhibition of IL-1 beta-mediated induction of intercellular adhesion molecule-1 (ICAM-1) and VCAM-1 expression [31]
Nitroxyl anion and nitroglycerin Reduction of intercellular adhesion molecule-1 (ICAM-1) and the cytokines monocyte chemoattractant protein 1 (MCP-1) and interleukin 6 (IL-6) [72]
Nitroglycerin Reduced plasma levels of C-reactive protein and sE-selectin [73]
Nitroglycerin No change in asymmetric dimethyl-arginine (ADMA), human soluble P-selectin, interleukin-6, tumor necrosis factor-alpha, intercellular adhesion molecule-1, and oxidized low-density lipoproteins in healthy volunteers [74]
Nicorandil Increased Mst1 and p-Mst1 levels in cardiomyocytes subjected to MI injury [75]
Nicorandil Inhibition of Toll-like receptor 4 (TLR4)-mediated myeloid differentiation primary response protein 88 (MyD88)-dependent nuclear factor-kappa B (NF-κB) signaling [76]
Nicorandil Inhibition of cyclic strain-induced IL-8 expression [77]
Nicorandil Reduced expression of 53 cytokines after percutaneous intervention in patients with coronary artery disease [78]
Nicorandil Inhibition of TNF-alpha in vitro [79]
Nicorandil Inhibition of the activation of NF-kappaB, expression of adhesion molecules, and cytokine production [80]
Nicorandil Inhibition of TNFalpha release from lymphocytes [80]
Inorganic nitrate Reduced systemic leukocyte rolling and adherence, circulating neutrophil numbers, neutrophil CD11b expression and myeloperoxidase activity [29]