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. 2020 Apr 22;21(8):2926. doi: 10.3390/ijms21082926

Figure 1.

Figure 1

GO analysis in 100 genes upregulated in JAK2V617F mutated patients.The GO analysis performed with the online tool GeneMANIA and GHATER showed the following results: 18 genes out of 365 belonging to the pathway of MHC class I-mediated antigen processing and presentation (p = 2.50 × 10−11) (a); 3 genes out of 19 belonging to the Immunoproteasome (IPs) (p = 0.0032) (a); the involvement of JAK-STAT signal pathways (p = 0.0074) (b); the Immuno-Defense-Response (40 out of 1234 genes) (p = 1.22 × 10−19) (c); 23 genes out of 189 belonging to the IFNG pathways (p = 5.19 × 10−22) (d).