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View full-text article in PMC

. 2020 Apr 22;21(8):2926. doi: 10.3390/ijms21082926

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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IPs genes expression in PB CD34⁺ Cells of JAK2^V617F mutated/wild-type PMF patients and healthy control subjects. The genes belonging to the IPs family are PSMB8 (a), PSMB9 (b), PSMB10 (c) and PSME1/2 (d). The patients affected by primary myelofibrosis express significant upregulated levels of IPs compared to healthy controls. In addition, the PMF patients mutated for JAK2^V617F express significant upregulated levels of IPs genes compared to wild-type patients. The JAK2 gene expression levels in PB CD34⁺ cells of PMF patients were significantly correlated with IPs genes expression. Data are expressed as z-score intensity expression levels and presented as vertical scatter dot plots. p values < 0.05 were considered to be statistically significant (* p < 0.05; *** p < 0.0005; **** p < 0.00005).