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. 2020 Apr 22;21(8):2926. doi: 10.3390/ijms21082926

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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IFNG genes pathways expression levels in PB CD34⁺ Cells of PMF patients. JAK2 is necessary and sufficient for IFNG-induced transcription of genes involved in immuno-response against antigens self/non-self. In our analysis, we showed that IFNG gene expression levels were significantly downregulated in PB CD34⁺ cells of PMF patients wild-type for JAK2^V617F mutation compared to healthy controls subjects (a), but not compared to JAK2^V617F mutated patients. Similar trends were observed for IRF1 (b) and IFNGR2 (d). The IFNGR1 modulation was an exception (c). GSEA of IFNG and STAT pathways. The data visualization was obtained by tool CIRCOS. The ribbons are expressed by weighted percentage (Q1 = red; Q2 = orange; Q3 = yellow; Q4 = purple). For Q1 and Q2 we used a transparency of 4 and no stroke (e). GSEA of IFNG and STAT1 pathways are expressed in a bar chart (f). Data are expressed as z-score intensity expression levels and presented as vertical scatter dot plots. p values < 0.05 were considered to be statistically significant (** p < 0.005; *** p < 0.0005; **** p < 0.00005).