Table 4.
Distribution of four SNPs and associations with NIHL.
| Genetic Model | Genotypes | Case | Control | p a | Adjusted OR 95% (CI) a | ||
|---|---|---|---|---|---|---|---|
| n = 633 | n = 625 | ||||||
| rs1136666 | n = 606 | % | n = 615 | % | |||
| Codominant | CC | 371 | 61.2 | 343 | 55.7 | 0.343 | 1.305 (0.752,2.266) |
| CG | 210 | 34.6 | 242 | 39.3 | 0.886 | 1.042 (0.594,1.829) | |
| GG | 25 | 4.1 | 30 | 4.8 | 1.000 (Reference) | ||
| Dominant | CC | 371 | 61.2 | 343 | 55.7 | 0.048 | 1.259 (1.002,1.583) |
| CG/GG | 235 | 38.7 | 272 | 44.1 | 1.000 (Reference) | ||
| Recessive | CG/CC | 581 | 95.8 | 585 | 95 | 0.517 | 1.197 (0.695,2.062) |
| GG | 25 | 4.1 | 30 | 4.8 | 1.000 (Reference) | ||
| Alleles | C | 952 | 78.5 | 928 | 75.4 | 1.000 (Reference) | |
| G | 260 | 21.5 | 302 | 24.6 | 0.059 | 0.830 (0.684,1.007) | |
| rs1803621 | n = 593 | % | n = 606 | % | |||
| Codominant | CC | 150 | 25.2 | 178 | 29.3 | 1.000 (Reference) | |
| TC | 321 | 54.1 | 322 | 53.1 | 0.222 | 1.181 (0.904,1.543) | |
| TT | 122 | 20.5 | 106 | 17.4 | 0.080 | 1.354 (0.964,1.902) | |
| Dominant | CC | 150 | 25.2 | 178 | 29.3 | 1.000 (Reference) | |
| TC/TT | 443 | 74.6 | 428 | 70.5 | 0.120 | 1.224 (0.949,1.580) | |
| Recessive | TC/CC | 471 | 79.3 | 500 | 82.4 | 1.000 (Reference) | |
| TT | 122 | 20.5 | 106 | 17.4 | 0.192 | 1.213 (0.908,1.621) | |
| Alleles | C | 621 | 52.4 | 678 | 55.9 | 1.000 (Reference) | |
| T | 565 | 47.6 | 534 | 44.1 | 0.073 | 1.166 (0.986,1.380) | |
| rs1060620 | n = 619 | % | n = 608 | % | |||
| Codominant | GG | 135 | 21.8 | 161 | 26.4 | 1.000 (Reference) | |
| AG | 346 | 55.8 | 326 | 53.6 | 0.093 | 1.265 (0.961,1.664) | |
| AA | 138 | 22.2 | 121 | 19.9 | 0.076 | 1.355 (0.969,1.894) | |
| Dominant | GG | 135 | 21.8 | 161 | 26.4 | 1.000 (Reference) | |
| AG/AA | 484 | 78.0 | 447 | 73.5 | 0.058 | 1.289 (0.991,1.676) | |
| Recessive | AG/GG | 481 | 77.6 | 487 | 80.0 | 1.000 (Reference) | |
| AA | 138 | 22.2 | 121 | 19.9 | 0.318 | 1.150 (0.874,1.515) | |
| Alleles | G | 616 | 49.8 | 648 | 53.3 | 1.000 (Reference) | |
| A | 622 | 50.2 | 568 | 46.7 | 0.070 | 1.167 (0.987,1.379) | |
| rs6489721 | n = 597 | % | n = 605 | % | |||
| Codominant | TT | 175 | 29.3 | 139 | 22.9 | 0.008 | 1.586 (1.131,2.225) |
| TC | 315 | 52.7 | 331 | 54.7 | 0.234 | 1.198 (0.890,1.612) | |
| CC | 107 | 17.9 | 135 | 22.3 | 1.000 (Reference) | ||
| Dominant | TT | 175 | 29.3 | 139 | 22.9 | 0.013 | 1.391 (1.073,1.804) |
| TC/CC | 422 | 70.6 | 466 | 77.0 | 1.000 (Reference) | ||
| Recessive | TC/TT | 490 | 82.0 | 470 | 77.6 | 0.061 | 1.312 (0.988,1.743) |
| CC | 107 | 17.9 | 135 | 22.3 | 1.000 (Reference) | ||
| Alleles | T | 665 | 55.7 | 609 | 50.3 | 0.006 | 1.262 (1.066,1.493) |
| C | 529 | 44.3 | 601 | 49.7 | 1.000 (Reference) | ||
a Adjusted for age, sex, smoking, drinking in logistic regression model. The bold in this table means p value < 0.05.