Table 6.
Crossover analysis of the interaction between rs6489721 and other factors on NIHL risk.
| Factors | Genotype | Case (N) | % | Control (N) | % | p a | OR (CI95%) a |
|---|---|---|---|---|---|---|---|
| Age | |||||||
| <40 | TT | 76 | 12.7 | 58 | 9.6 | 1.0 | |
| <40 | TC + CC | 188 | 31.5 | 206 | 34.0 | 0.077 | 0.700 (0.472–1.040) |
| ≥40 | TT | 99 | 16.6 | 81 | 13.4 | 0.728 | 0.923 (0.588–1.450) |
| ≥40 | TC + CC | 234 | 39.2 | 260 | 43.0 | 0.050 | 0.679 (0.462–1.000) |
| Exposure level [dB(A)] | |||||||
| ≤85 | TT | 64 | 12.5 | 40 | 8.6 | 1.0 | |
| ≤85 | TC + CC | 154 | 30.1 | 129 | 27.7 | 0.205 | 0.742 (0.469–1.177) |
| 85–92 | TT | 35 | 6.8 | 22 | 4.7 | 0.939 | 0.974 (0.501–1.896) |
| 85–92 | TC + CC | 73 | 14.3 | 71 | 15.2 | 0.075 | 0.627 (0.374–1.049) |
| >92 | TT | 55 | 10.8 | 48 | 10.3 | 0.171 | 0.676 (0.386–1.184) |
| >92 | TC + CC | 130 | 25.4 | 156 | 33.5 | 0.003 | 0.495 (0.311 – 0.790) |
a Adjusted for age, sex, smoking, drinking in the logistic regression model. The bold in this table means p value <0.05.