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. 2020 Apr 15;21(8):2752. doi: 10.3390/ijms21082752

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Mark4 decreased browning of white adipose tissue via promoting autophagy. (A) Oil red O staining after interference with Mark4 and the addition of 3-methyl adenine (3-MA) under the condition of serum starvation. Scale bar, 100 µm (B) Oil red O staining after interference with Mark4 and the addition of 3-MA under the treatment of Rapa. Scale bar, 100 µm. (C) Relative mRNA level of the marker genes of brown adipose tissue. (D) Protein level of the marker genes of brown adipose tissue. (E) Relative mRNA level of thermogenesis genes (n = 6). (F) Relative mRNA level of thermogenesis genes (n = 6). (G) Protein level of UCP1, PGC1a, and Prdm16. (H) Protein level of UCP1, PGC1a, and Prdm16. * p < 0.05, ** p < 0.01, N.S.